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Vitamin K Deficiency Linked to Poor Lung Function: Asthma, COPD, and More

Vitamin K Deficiency Linked to Poor Lung Function: Asthma, COPD, and More

Aug 19, 2023
Vitamin K Food Sources

People with low levels of vitamin K in their blood may suffer from poor lung function and conditions like asthma and COPD, according to a study. Although the findings do not change current vitamin K intake recommendations, they support further research, including possible vitamin K supplementation for certain individuals.

A study published in ERJ Open Research reveals a connection between low levels of vitamin K in the blood and poor lung function, including conditions like asthma and COPD.

People with low levels of vitamin K in their blood are more likely to have poor lung function and to say they suffer from asthma, chronic obstructive pulmonary disease (COPD), and wheezing, according to a study published on August 9 in the journal ERJ Open Research.

Vitamin K is found in leafy green vegetables, vegetable oils, and cereal grains. It plays a role in blood clotting, and so helps the body to heal wounds, but researchers know very little about its role in lung health.

Torkil Jespersen

Portrait photo of researcher Torkil Jespersen. Credit: Torkil Jespersen/ERJ Open Research

Researchers say their new findings do not alter the current advice on vitamin K intake, but they do support further research to see if some people could benefit from taking vitamin K supplements.

The study was conducted by a team of Danish researchers at Copenhagen University Hospital and the University of Copenhagen. It involved a group of 4,092 people aged between 24 and 77 years living in Copenhagen.

Study participants took part in lung function testing, called spirometry, gave blood samples, and answered questionnaires on their health and lifestyle. The blood tests included a marker of low levels of vitamin K in the body called dp-ucMGP. Spirometry measures the amount of air a person can breathe out in one second (forced expiratory volume or FEV1) and the total volume of air they can breathe in one forced breath (forced vital capacity or FVC).

Findings on Vitamin K and Lung Function

The researchers found that people with markers of low levels of vitamin K had lower FEV1 and lower FVC on average. People with lower levels of vitamin K were also more likely to say they had COPD, asthma, or wheezing.

Researcher, Dr Torkil Jespersen said: “We already know that vitamin K has an important role in the blood, and research is beginning to show that it’s also important in heart and bone health, but there’s been very little research looking at vitamin K and the lungs. To our knowledge, this is the first study on vitamin K and lung function in a large general population. Our results suggest that vitamin K could play a part in keeping our lungs healthy.

Food Rich in Vitamin K

Vitamin K, essential for blood clotting and bone health, exists mainly in two forms: K1 and K2. Vitamin K1 is primarily found in green leafy vegetables like kale, spinach, and broccoli, as well as certain vegetable oils. On the other hand, Vitamin K2 is prevalent in fermented foods like natto, animal products such as liver and egg yolks, fatty meats, and some dairy products like hard cheeses. Including a diverse range of these foods in one’s diet ensures a balanced intake of both forms of this vital nutrient.

Implications and Ongoing Research

“On their own, our findings do not alter current recommendations for vitamin K intake, but they do suggest that we need more research on whether some people, such as those with lung disease, could benefit from vitamin K supplementation.”

The research team is already working on a large clinical trial comparing vitamin K supplementation with a placebo (dummy pill) to look at any effects on heart and bone health in the general population (the InterVitaminK trial). Based on their new results, they will now include analyses of lung function in this trial.

Expert Commentary

Dr. Apostolos Bossios from Karolinska Institutet in Sweden is Secretary of the European Respiratory Society’s assembly on Airway diseases, asthma, COPD, and chronic cough, and was not involved in the research. He said: “This study suggests that people with low levels of vitamin K in their blood may have poorer lung function. Further research will help us understand more about this link and see whether increasing vitamin K can improve lung function or not.

“In the meantime, we can all try to eat a healthy, balanced diet to support our overall health, and we can protect our lungs by not smoking, taking part in exercise, and doing all we can to cut air pollution.”

Reference: “The association of vitamin K status with lung function and disease in a general population” by Torkil Jespersen, Freja Bach Kampmann, Thomas Meinertz Dantoft, Niklas Rye Jørgensen, Line Lund Kårhus, Flemming Madsen, Allan Linneberg and Sanne Marie Thysen, 9 August 2023, ERJ Open Research.
DOI: 10.1183/23120541.00208-2023


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